CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10790 | S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal |
Domain Context
CATH Clusters
| Superfamily | S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal |
| Functional Family |
Enzyme Information
| 2.5.1.94 |
Adenosyl-chloride synthase.
based on mapping to UniProt A4X3Q0
S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine.
-!- This enzyme, isolated from the marine bacterium Salinispora tropica, catalyzes an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. -!- The enzyme is very similar to EC 2.5.1.63 but does not accept fluoride.
|
UniProtKB Entries (1)
| A4X3Q0 |
SALL_SALTO
Salinispora tropica CNB-440
Adenosyl-chloride synthase
|
PDB Structure
| PDB | 2Q6L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Discovery and characterization of a marine bacterial SAM-dependent chlorinase
Nat.Chem.Biol.
|