CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.420 | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain |
Domain Context
CATH Clusters
| Superfamily | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain |
| Functional Family | 3-hydroxy-3-methylglutaryl coenzyme A reductase |
Enzyme Information
| 1.1.1.34 |
Hydroxymethylglutaryl-CoA reductase (NADPH).
based on mapping to UniProt P04035
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.
|
UniProtKB Entries (1)
| P04035 |
HMDH_HUMAN
Homo sapiens
3-hydroxy-3-methylglutaryl-coenzyme A reductase
|
PDB Structure
| PDB | 2Q6B |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Bioorg.Med.Chem.Lett.
|