CATH Classification

Domain Context

CATH Clusters

Superfamily Molybdopterin biosynthesis MoaE subunit
Functional Family Molybdopterin converting factor subunit 2

Enzyme Information

2.8.1.12
Molybdopterin synthase.
based on mapping to UniProt P65401
Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H(2)O = molybdopterin + 2 [molybdopterin- synthase sulfur-carrier protein].
-!- Catalyzes the synthesis of molybdopterin from cyclic pyranopterin phosphate. -!- Two sulfur atoms are transferred to cyclic pyranopterin phosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor. -!- Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur- carrier proteins) that are thiocarboxylated at the C-terminus by EC 2.8.1.11, molybdopterin synthase sulfurtransferase. -!- The reaction occurs in prokaryotes and eukaryotes.

UniProtKB Entries (1)

Q7A441
MOAD_STAAN
Staphylococcus aureus subsp. aureus N315
Molybdopterin synthase sulfur carrier subunit

PDB Structure

PDB 2Q5W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
Daniels, J.N., Wuebbens, M.M., Rajagopalan, K.V., Schindelin, H.
Biochemistry