CATH Domain 2q5aA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.20	Single Sheet
	2.20.70	Ubiquitin Ligase Nedd4; Chain: W;
	2.20.70.10

Domain Context

CATH Clusters

Superfamily	2.20.70.10
Functional Family	Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q13526

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13526

PIN1_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PDB Structure

PDB	2Q5A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural basis for high-affinity peptide inhibition of human Pin1. Zhang, Y., Daum, S., Wildemann, D., Zhou, X.Z., Verdecia, M.A., Bowman, M.E., Lucke, C., Hunter, T., Lu, K.P., Fischer, G., Noel, J.P. Acs Chem.Biol.