CATH Domain 2q0zX03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.150	C2 domain

Domain Context

CATH Clusters

Superfamily	C2 domain
Functional Family	U5 small nuclear ribonucleoprotein 200 kDa helicase

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt O75643

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O75643

U520_HUMAN

Homo sapiens

U5 small nuclear ribonucleoprotein 200 kDa helicase

PDB Structure

PDB	2Q0Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Q9P172/Sec63 from Homo sapiens. Benach, J., Neely, H., Abashidze, M., Edstrom, W.C., Seetharaman, J., Zhao, L., Fang, Y., Cunningham, K., Owens, L., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Tong, L., Hunt, J.F. To be Published