CATH Domain 2q0zX02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.150	DNA polymerase; domain 1
	1.10.150.20	5' to 3' exonuclease, C-terminal subdomain

Domain Context

CATH Clusters

Superfamily	5' to 3' exonuclease, C-terminal subdomain
Functional Family	U5 small nuclear ribonucleoprotein kDa helicase

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt O75643

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O75643

U520_HUMAN

Homo sapiens

U5 small nuclear ribonucleoprotein 200 kDa helicase

PDB Structure

PDB	2Q0Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Q9P172/Sec63 from Homo sapiens. Benach, J., Neely, H., Abashidze, M., Edstrom, W.C., Seetharaman, J., Zhao, L., Fang, Y., Cunningham, K., Owens, L., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Tong, L., Hunt, J.F. To be Published