CATH Domain 2pu7A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family

Enzyme Information

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate hydrolase.

based on mapping to UniProt P47229

2,6-dioxo-6-phenylhexa-3-enoate + H(2)O = benzoate + 2-oxopent-4-enoate.

-!- Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 by ring-fission at a -CO-C bond. -!- Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.

UniProtKB Entries (1)

P47229

BPHD_PARXL

Paraburkholderia xenovorans LB400

2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase

PDB Structure

PDB	2PU7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The Tautomeric Half-reaction of BphD, a C-C Bond Hydrolase: KINETIC AND STRUCTURAL EVIDENCE SUPPORTING A KEY ROLE FOR HISTIDINE 265 OF THE CATALYTIC TRIAD. Horsman, G.P., Bhowmik, S., Seah, S.Y., Kumar, P., Bolin, J.T., Eltis, L.D. J.Biol.Chem.