CATH Domain 2pqgA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.420	Ricin (A subunit); domain 1
	3.40.420.10	Ricin (A subunit), domain 1

Domain Context

CATH Clusters

Superfamily	Ricin (A subunit), domain 1
Functional Family

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P25891

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P25891

RIP3_MAIZE

Zea mays

Ribosome-inactivating protein 3

PDB Structure

PDB	2PQG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site. Mak, A.N., Wong, Y.T., An, Y.J., Cha, S.S., Sze, K.H., Au, S.W., Wong, K.B., Shaw, P.C. Nucleic Acids Res.