CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family Amine oxidase

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt Q29437
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

Q29437
AOCX_BOVIN
Bos taurus
Primary amine oxidase, liver isozyme

PDB Structure

PDB 2PNC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Multiple binding sites for substrates and modulators of semicarbazide-sensitive amine oxidases: kinetic consequences
Holt, A., Smith, D.J., Cendron, L., Zanotti, G., Rigo, A., Di Paolo, M.L.
Mol.Pharmacol.