CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family PHO system negative regulator

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P17157
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P20052
PHO80_YEAST
Saccharomyces cerevisiae S288C
PHO85 cyclin PHO80

PDB Structure

PDB 2PMI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the Pho85-Pho80 CDK-Cyclin Complex of the Phosphate-Responsive Signal Transduction Pathway
Huang, K., Ferrin-O'Connell, I., Zhang, W., Leonard, G.A., O'Shea, E.K., Quiocho, F.A.
Mol.Cell