CATH Domain 2pleA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Enzyme Information

3.1.4.11

Phosphoinositide phospholipase C.

based on mapping to UniProt P08487

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (2)

P08487	PLCG1_BOVIN Bos taurus 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
P09619	PGFRB_HUMAN Homo sapiens Platelet-derived growth factor receptor beta

PDB Structure

PDB	2PLE
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Pascal, S.M., Singer, A.U., Gish, G., Yamazaki, T., Shoelson, S.E., Pawson, T., Kay, L.E., Forman-Kay, J.D. Cell(Cambridge,Mass.)