CATH Domain 2picA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.40	Barwin-like endoglucanases
	2.40.40.10	RlpA-like domain

Domain Context

CATH Clusters

Superfamily	RlpA-like domain
Functional Family	Membrane-bound lytic murein transglycosylase A

Enzyme Information

4.2.2.n1

Peptidoglycan lytic exotransglycosylase.

based on mapping to UniProt P0A935

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

UniProtKB Entries (1)

P0A935

MLTA_ECOLI

Escherichia coli K-12

Membrane-bound lytic murein transglycosylase A

PDB Structure

PDB	2PIC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage van Straaten, K.E., Barends, T.R., Dijkstra, B.W., Thunnissen, A.M.W.H. J.Biol.Chem.