CATH Domain 2ph6A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Beta-secretase 1

Enzyme Information

3.4.23.46

Memapsin 2.

based on mapping to UniProt P56817

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.

-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817

BACE1_HUMAN

Homo sapiens

Beta-secretase 1

PDB Structure

PDB	2PH6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors. Lindsley, S.R., Moore, K.P., Rajapakse, H.A., Selnick, H.G., Young, M.B., Zhu, H., Munshi, S., Kuo, L., McGaughey, G.B., Colussi, D., Crouthamel, M.C., Lai, M.T., Pietrak, B., Price, E.A., Sankaranarayanan, S., Simon, A.J., Seabrook, G.R., Hazuda, D.J., Pudvah, N.T., Hochman, J.H., Graham, S.L., Vacca, J.P., Nantermet, P.G. Bioorg.Med.Chem.Lett.