CATH Domain 2pgdA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44

Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).

based on mapping to UniProt P00349

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.

-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P00349

6PGD_SHEEP

Ovis aries

6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB	2PGD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The structure of 6-phosphogluconate dehydrogenase refined at 2.5 A resolution. Adams, M.J., Gover, S., Leaback, R., Phillips, C., Somers, D.O. Acta Crystallogr.,Sect.B