CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Hyaluronidase

Enzyme Information

3.2.1.35
Hyaluronoglucosaminidase.
based on mapping to UniProt Q12794
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
-!- Also hydrolyzes 1,4-beta-D-glycosidic linkages between N-acetyl- galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan. -!- Formerly EC 3.2.1.34.

UniProtKB Entries (1)

Q12794
HYAL1_HUMAN
Homo sapiens
Hyaluronidase-1

PDB Structure

PDB 2PE4
External Links
Method X-RAY DIFFRACTION
Organism Drosophila
Primary Citation
Structure of Human Hyaluronidase-1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis
Chao, K.L., Muthukumar, L., Herzberg, O.
Biochemistry
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