CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1050 | Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 |
|
1.20.1050.10 |
Domain Context
CATH Clusters
| Superfamily | 1.20.1050.10 |
| Functional Family | Prostaglandin E synthase 2 |
Enzyme Information
| 5.3.99.3 |
Prostaglandin-E synthase.
based on mapping to UniProt Q9N0A4
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.
|
UniProtKB Entries (1)
| Q9N0A4 |
PGES2_MACFA
Macaca fascicularis
Prostaglandin E synthase 2
|
PDB Structure
| PDB | 2PBJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
Biochemistry
|
