CATH Domain 2p8eA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.40	Phosphatase 2c; domain 1
	3.60.40.10	PPM-type phosphatase domain

Domain Context

CATH Clusters

Superfamily	PPM-type phosphatase domain
Functional Family	protein phosphatase 1B isoform X1

Enzyme Information

3.1.3.16

Protein-serine/threonine phosphatase.

based on mapping to UniProt O75688

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.

-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

O75688

PPM1B_HUMAN

Homo sapiens

Protein phosphatase 1B

PDB Structure

PDB	2P8E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural genomics of protein phosphatases. Almo, S.C., Bonanno, J.B., Sauder, J.M., Emtage, S., Dilorenzo, T.P., Malashkevich, V., Wasserman, S.R., Swaminathan, S., Eswaramoorthy, S., Agarwal, R., Kumaran, D., Madegowda, M., Ragumani, S., Patskovsky, Y., Alvarado, J., Ramagopal, U.A., Faber-Barata, J., Chance, M.R., Sali, A., Fiser, A., Zhang, Z.Y., Lawrence, D.S., Burley, S.K. J.Struct.Funct.Genom.