CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.630 | Aminopeptidase |
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3.40.630.30 | Gcn5-related N-acetyltransferase (GNAT) |
Domain Context
CATH Clusters
Superfamily | 3.40.630.30 |
Functional Family | Glycylpeptide N-tetradecanoyltransferase |
Enzyme Information
2.3.1.97 |
Glycylpeptide N-tetradecanoyltransferase.
based on mapping to UniProt P14743
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal- N-tetradecanoylglycyl-[protein].
-!- The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. -!- It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. -!- The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.
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UniProtKB Entries (1)
P14743 |
NMT_YEAST
Saccharomyces cerevisiae S288C
Glycylpeptide N-tetradecanoyltransferase
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PDB Structure
PDB | 2P6G |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
J.Biol.Chem.
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