CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
| 1.1.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt Q91WR5
|
| 1.1.1.209 |
3(or 17)-alpha-hydroxysteroid dehydrogenase.
based on mapping to UniProt Q91WR5
Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H.
-!- Acts on the 3-alpha-hydroxy group of androgens of the 5-alpha- androstane series; and also, more slowly, on the 17-alpha-hydroxyl group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51).
|
UniProtKB Entries (1)
| Q91WR5 |
AK1CL_MOUSE
Mus musculus
Aldo-keto reductase family 1 member C21
|
PDB Structure
| PDB | 2P5N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
Acta Crystallogr.,Sect.F
|
