CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor Tie-1

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q02763
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q02763
TIE2_HUMAN
Homo sapiens
Angiopoietin-1 receptor

PDB Structure

PDB 2P4I
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
Hodous, B.L., Geuns-Meyer, S.D., Hughes, P.E., Albrecht, B.K., Bellon, S., Bready, J., Caenepeel, S., Cee, V.J., Chaffee, S.C., Coxon, A., Emery, M., Fretland, J., Gallant, P., Gu, Y., Hoffman, D., Johnson, R.E., Kendall, R., Kim, J.L., Long, A.M., Morrison, M., Olivieri, P.R., Patel, V.F., Polverino, A., Rose, P., Tempest, P., Wang, L., Whittington, D.A., Zhao, H.
J.Med.Chem.