CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.348
(3R)-2'-hydroxyisoflavanone reductase.
based on mapping to UniProt Q40316
A (4R)-4,2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + NADPH.
-!- This plant enzyme participates in the biosynthesis of the pterocarpan phytoalexins medicarpin, maackiain, and several forms of glyceollin. -!- The enzyme has a strict stereo specificity for the 3R-isoflavanones. -!- Formerly EC 1.1.1.246.

UniProtKB Entries (1)

Q40316
VESTR_MEDSA
Medicago sativa
Vestitone reductase

PDB Structure

PDB 2P4H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Vestitone Reductase from Alfalfa (Medicago sativa L.).
Shao, H., Dixon, R.A., Wang, X.
J.Mol.Biol.