CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase 10A

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q9QYJ6
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q9QYJ6
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

Q9QYJ6
PDE10_RAT
Rattus norvegicus
CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

PDB Structure

PDB 2OVV
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors
Chappie, T.A., Humphrey, J.M., Allen, M.P., Estep, K.G., Fox, C.B., Lebel, L.A., Liras, S., Marr, E.S., Menniti, F.S., Pandit, J., Schmidt, C.J., Tu, M., Williams, R.D., Yang, F.V.
J.Med.Chem.