CATH Classification
Domain Context
CATH Clusters
Superfamily | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
Functional Family | Phosphodiesterase 10A |
Enzyme Information
3.1.4.17 |
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q9QYJ6
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
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3.1.4.35 |
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q9QYJ6
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
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UniProtKB Entries (1)
Q9QYJ6 |
PDE10_RAT
Rattus norvegicus
CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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PDB Structure
PDB | 2OVV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Spodoptera |
Primary Citation |
Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors
J.Med.Chem.
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