CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.429 | Macrophage Migration Inhibitory Factor |
|
3.30.429.10 | Macrophage Migration Inhibitory Factor |
Domain Context
CATH Clusters
| Superfamily | Macrophage Migration Inhibitory Factor |
| Functional Family | Macrophage migration inhibitory factor |
Enzyme Information
| 5.3.3.12 |
L-dopachrome isomerase.
based on mapping to UniProt P14174
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
-!- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate). -!- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
|
| 5.3.2.1 |
Phenylpyruvate tautomerase.
based on mapping to UniProt P14174
Keto-phenylpyruvate = enol-phenylpyruvate.
-!- Also acts on other arylpyruvates.
|
UniProtKB Entries (1)
| P14174 |
MIF_HUMAN
Homo sapiens
Macrophage migration inhibitory factor
|
PDB Structure
| PDB | 2OOH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.
J.Biol.Chem.
|
