CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.1220 | TPP-binding domain |
Domain Context
CATH Clusters
Superfamily | TPP-binding domain |
Functional Family |
Enzyme Information
7.1.1.1 |
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt P0C188
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC 1.6.1.5.
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UniProtKB Entries (2)
Q2RSB2 |
PNTAA_RHORT
Rhodospirillum rubrum ATCC 11170
NAD(P) transhydrogenase subunit alpha part 1
|
P0C188 |
PNTB_RHORU
Rhodospirillum rubrum
NAD(P) transhydrogenase subunit beta
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PDB Structure
PDB | 2OO5 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structures of the dI(2)dIII(1) Complex of Proton-Translocating Transhydrogenase with Bound, Inactive Analogues of NADH and NADPH Reveal Active Site Geometries
Biochemistry
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