CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1150 | Aspartate Aminotransferase, domain 1 |
|
3.90.1150.10 | Aspartate Aminotransferase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Aspartate Aminotransferase, domain 1 |
| Functional Family | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase |
Enzyme Information
| 2.6.1.106 |
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase.
based on mapping to UniProt Q9ZGH4
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3- dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate.
-!- The enzyme is involved in the biosynthesis of dTDP-alpha-D- desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. -!- The reaction occurs in the reverse direction.
|
UniProtKB Entries (1)
| Q9ZGH4 |
DESV_STRVZ
Streptomyces venezuelae
DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
|
PDB Structure
| PDB | 2OGA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Molecular architecture of DesV from Streptomyces venezuelae: A PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
Protein Sci.
|
