CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06239
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06239
LCK_HUMAN
Homo sapiens
Tyrosine-protein kinase Lck

PDB Structure

PDB 2OF2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties.
Martin, M.W., Newcomb, J., Nunes, J.J., Bemis, J.E., McGowan, D.C., White, R.D., Buchanan, J.L., Dimauro, E.F., Boucher, C., Faust, T., Hsieh, F., Huang, X., Lee, J.H., Schneider, S., Turci, S.M., Zhu, X.
Bioorg.Med.Chem.Lett.