CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Erythronate-4-phosphate dehydrogenase |
Enzyme Information
| 1.1.1.290 |
4-phosphoerythronate dehydrogenase.
based on mapping to UniProt Q9I3W9
4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH.
-!- This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. -!- The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+). -!- In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid. -!- Cf. EC 1.1.1.399.
|
UniProtKB Entries (1)
| Q9I3W9 |
PDXB_PSEAE
Pseudomonas aeruginosa PAO1
Erythronate-4-phosphate dehydrogenase
|
PDB Structure
| PDB | 2O4C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of d-Erythronate-4-phosphate Dehydrogenase Complexed with NAD
J.Mol.Biol.
|