CATH Domain 2o3eA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1050	Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
	1.20.1050.40	Endopeptidase. Chain P; domain 1

Domain Context

CATH Clusters

Superfamily	Endopeptidase. Chain P; domain 1
Functional Family	Thimet oligopeptidase 1

Enzyme Information

3.4.24.16

Neurolysin.

based on mapping to UniProt P42676

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

-!- No absolute requirement for a prolyl bond; the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. -!- Belongs to peptidase family M3.

UniProtKB Entries (1)

P42676

NEUL_RAT

Rattus norvegicus

Neurolysin, mitochondrial

PDB Structure

PDB	2O3E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. Lim, E.J., Sampath, S., Coll-Rodriguez, J., Schmidt, J., Ray, K., Rodgers, D.W. J.Biol.Chem.