CATH Domain 2nw7A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.58	Methane Monooxygenase Hydroxylase; Chain G, domain 1
	1.20.58.480

Domain Context

CATH Clusters

Superfamily	1.20.58.480
Functional Family	Tryptophan 2,3-dioxygenase

Enzyme Information

1.13.11.11

Tryptophan 2,3-dioxygenase.

based on mapping to UniProt Q8PDA8

L-tryptophan + O(2) = N-formyl-L-kynurenine.

-!- Catalyzes, together with EC 1.13.11.52, the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. -!- Specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan. -!- Formerly EC 1.11.1.4 and EC 1.13.1.12.

UniProtKB Entries (1)

Q8PDA8

T23O_XANCP

Xanthomonas campestris pv. campestris str. ATCC 33913

Tryptophan 2,3-dioxygenase

PDB Structure

PDB	2NW7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase. Forouhar, F., Anderson, J.L., Mowat, C.G., Vorobiev, S.M., Hussain, A., Abashidze, M., Bruckmann, C., Thackray, S.J., Seetharaman, J., Tucker, T., Xiao, R., Ma, L.C., Zhao, L., Acton, T.B., Montelione, G.T., Chapman, S.K., Tong, L. Proc.Natl.Acad.Sci.Usa