CATH Domain 2nqdB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Cathepsin S

Enzyme Information

3.4.22.15

Cathepsin L.

based on mapping to UniProt P07711

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

-!- A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64. -!- Belongs to peptidase family C1.

UniProtKB Entries (2)

Q966X9	CHAG_TRYCR Trypanosoma cruzi Chagasin
P07711	CATL1_HUMAN Homo sapiens Cathepsin L1

PDB Structure

PDB	2NQD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease Ljunggren, A., Redzynia, I., Alvarez-Fernandez, M., Abrahamson, M., Mort, J.S., Krupa, J.C., Jaskolski, M., Bujacz, G. J.Mol.Biol.