CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.210
Functional Family

Enzyme Information

2.1.1.14
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
based on mapping to UniProt Q8CWX6
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.
-!- Requires phosphate. -!- The enzyme from Escherichia coli also requires a reducing system. -!- Unlike EC 2.1.1.13 this enzyme does not contain cobalamin.

UniProtKB Entries (1)

Q8CWX6
METE_STRMU
Streptococcus mutans UA159
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

PDB Structure

PDB 2NQ5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of methyltransferase from Streptococcus mutans
Fedorov, A.A., Fedorov, E.V., Sauder, J.M., Burley, S.K., Almo, S.C.
To be Published