CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.58 | Methane Monooxygenase Hydroxylase; Chain G, domain 1 |
|
1.20.58.1300 |
Domain Context
CATH Clusters
| Superfamily | 1.20.58.1300 |
| Functional Family | (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase |
Enzyme Information
| 1.13.11.80 |
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase.
based on mapping to UniProt Q8KLK7
(3,5-dihydroxyphenyl)acetyl-CoA + O(2) = 2-(3,5-dihydroxyphenyl)-2- oxoacetate + CoA.
-!- The enzyme, characterized from bacteria Streptomyces toyocaensis and Amycolatopsis orientalis, is involved in the biosynthesis of (3,5- dihydroxyphenyl)glycine, a component of the glycopeptide antibiotic vancomycin.
|
UniProtKB Entries (1)
| Q8KLK7 |
DPGC_STRTO
Streptomyces toyocaensis
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
|
PDB Structure
| PDB | 2NP9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis.
Nature
|
