CATH Domain 2ms4A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.100	Cyclophilin
	2.40.100.10	Cyclophilin-like

Domain Context

CATH Clusters

Superfamily	Cyclophilin-like
Functional Family	Peptidyl-prolyl cis-trans isomerase A

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P62937

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P46108

CRK_HUMAN

Homo sapiens

Adapter molecule crk

PDB Structure

PDB	2MS4
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway. Saleh, T., Jankowski, W., Sriram, G., Rossi, P., Shah, S., Lee, K.B., Cruz, L.A., Rodriguez, A.J., Birge, R.B., Kalodimos, C.G. Nat.Chem.Biol.