CATH Domain 2mp0A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.50	3-Layer(bba) Sandwich
	3.50.30	Glucose Oxidase; domain 1
	3.50.30.10	Phosphohistidine domain

Domain Context

CATH Clusters

Superfamily	Phosphohistidine domain
Functional Family	Phosphoenolpyruvate-protein phosphotransferase

Enzyme Information

2.7.3.9

Phosphoenolpyruvate--protein phosphotransferase.

based on mapping to UniProt P08839

Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)- phospho-L-histidine.

-!- Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. -!- A similar reaction where the protein is the enzyme EC 2.7.9.2 is part of the mechanism of that enzyme.

UniProtKB Entries (1)

P08839

PT1_ECOLI

Escherichia coli K-12

Phosphoenolpyruvate-protein phosphotransferase

PDB Structure

PDB	2MP0
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Visualizing an ultra-weak protein-protein interaction in phosphorylation signaling. Xing, Q., Huang, P., Yang, J., Sun, J.Q., Gong, Z., Dong, X., Guo, D.C., Chen, S.M., Yang, Y.H., Wang, Y., Yang, M.H., Yi, M., Ding, Y.M., Liu, M.L., Zhang, W.P., Tang, C. Angew.Chem.Int.Ed.Engl.