1 keywords

CATH Domain 2mbrA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.78 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 1
Homologous Superfamily 3.90.78.10 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain

Domain Context

CATH Clusters

Superfamily UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
Functional Family UDP-N-acetylenolpyruvoylglucosamine reductase

Enzyme Information

1.3.1.98
UDP-N-acetylmuramate dehydrogenase.
based on mapping to UniProt P08373
UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3- O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.
-!- NADH can to a lesser extent replace NADPH. -!- Formerly EC 1.1.1.158.

UniProtKB Entries (1)

P08373
MURB_ECOLI
Escherichia coli K-12
UDP-N-acetylenolpyruvoylglucosamine reductase

PDB Structure

PDB 2MBR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolution.
Benson, T.E., Walsh, C.T., Hogle, J.M.
Biochemistry