CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.250.1720
Functional Family

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q96RU2
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q96RU2
UBP28_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 28

PDB Structure

PDB 2LVA
External Links
Method SOLUTION NMR
Organism
Primary Citation
NMR solution structure of the N-terminal domain of human USP28
Lemak, A., Yee, A., Houliston, S., Garcia, M., Dhe-Paganon, S., Montelione, G.T., Arrowsmith, C.
To be Published