CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.100 |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.100 |
| Functional Family | ATPase copper transporting beta |
Enzyme Information
| 7.2.2.8 |
P-type Cu(+) transporter.
based on mapping to UniProt P35670
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC 7.2.2.9, which mainly transports the divalent copper ion. -!- Formerly EC 3.6.3.54.
|
UniProtKB Entries (1)
| P35670 |
ATP7B_HUMAN
Homo sapiens
Copper-transporting ATPase 2
|
PDB Structure
| PDB | 2LQB |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification.
Biochem.J.
|
