CATH Domain 2lk4A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.330	Nucleotidyltransferases domain 2

Domain Context

CATH Clusters

Superfamily	Nucleotidyltransferases domain 2
Functional Family	protein-tyrosine kinase 2-beta isoform X1

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q14289

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q14289

FAK2_HUMAN

Homo sapiens

Protein-tyrosine kinase 2-beta

PDB Structure

PDB	2LK4
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Structural and Mechanistic Insights into the Interaction between Pyk2 and Paxillin LD Motifs. Vanarotti, M.S., Miller, D.J., Guibao, C.D., Nourse, A., Zheng, J.J. J.Mol.Biol.