CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.250.890
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P56568
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P56568
RIP1_LUFAE
Luffa aegyptiaca
Ribosome-inactivating protein luffin P1

PDB Structure

PDB 2L37
External Links
Method SOLUTION NMR
Organism
Primary Citation
Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical).
Ng, Y.M., Yang, Y., Sze, K.H., Zhang, X., Zheng, Y.T., Shaw, P.C.
J.Struct.Biol.