CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.250.1630
Functional Family

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4
POLI_HUMAN
Homo sapiens
DNA polymerase iota

PDB Structure

PDB 2L0F
External Links
Method SOLUTION NMR
Organism
Primary Citation
Structural Basis of Ubiquitin Recognition by Translesion Synthesis DNA Polymerase iota.
Cui, G., Benirschke, R.C., Tuan, H.F., Juranic, N., Macura, S., Botuyan, M.V., Mer, G.
Biochemistry
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