CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.490 | Hypothetical upf0131 protein ytfp |
|
3.10.490.10 | Gamma-glutamyl cyclotransferase-like |
Domain Context
CATH Clusters
| Superfamily | Gamma-glutamyl cyclotransferase-like |
| Functional Family | Gamma-glutamylaminecyclotransferase A |
Enzyme Information
| 4.3.2.8 |
Gamma-glutamylamine cyclotransferase.
based on mapping to UniProt Q923B0
Epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline.
-!- The enzyme, found in vertebrates, has no activity toward alpha- (gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9). -!- The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
|
UniProtKB Entries (1)
| Q923B0 |
GGACT_MOUSE
Mus musculus
Gamma-glutamylaminecyclotransferase
|
PDB Structure
| PDB | 2KL2 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites.
Acta Crystallogr.,Sect.F
|
