CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.29.110
Functional Family inositol polyphosphate 5-phosphatase OCRL-1

Enzyme Information

3.1.3.36
Phosphoinositide 5-phosphatase.
based on mapping to UniProt Q01968
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 4-phosphate + phosphate.
-!- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3) and/or Ins(1,3,4,5)P(4). -!- They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed. -!- They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. -!- All of them can use either or both of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as substrates; this is the main property that distinguishes them from EC 3.1.3.56.

UniProtKB Entries (1)

Q01968
OCRL_HUMAN
Homo sapiens
Inositol polyphosphate 5-phosphatase OCRL-1

PDB Structure

PDB 2KIE
External Links
Method SOLUTION NMR
Organism
Primary Citation
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
Mao, Y., Balkin, D.M., Zoncu, R., Erdmann, K.S., Tomasini, L., Hu, F., Jin, M.M., Hodsdon, M.E., De Camilli, P.
Embo J.