CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.10 | Thrombin, subunit H | |
2.40.10.330 |
Domain Context
CATH Clusters
Superfamily | 2.40.10.330 |
Functional Family | Peptidyl-prolyl cis-trans isomerase |
Enzyme Information
5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt P0A9K9
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
|
UniProtKB Entries (1)
P0A9K9 |
SLYD_ECOLI
Escherichia coli K-12
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD
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PDB Structure
PDB | 2K8I |
External Links | |
Method | SOLUTION NMR |
Organism | |
Primary Citation |
NMR solution structure of SlyD from Escherichia coli: spatial separation of prolyl isomerase and chaperone function.
J.Mol.Biol.
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