CATH Domain 2k7vA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.100	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain Context

CATH Clusters

Superfamily	2.40.50.100
Functional Family	Acetyltransferase component of pyruvate dehydrogenase complex

Enzyme Information

2.3.1.12

Dihydrolipoyllysine-residue acetyltransferase.

based on mapping to UniProt P06959

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)- (S-acetyldihydrolipoyl)lysine.

-!- A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1 and EC 1.8.1.4. -!- The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalyzed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.

UniProtKB Entries (1)

P06959

ODP2_ECOLI

Escherichia coli K-12

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

PDB Structure

PDB	2K7V
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	A surface loop directs conformational switching of a lipoyl domain between a folded and a novel misfolded structure. Stott, K.M., Yusof, A.M., Perham, R.N., Jones, D.D. Structure