CATH Classification

Domain Context

CATH Clusters

Superfamily Hemopexin-like domain
Functional Family Matrix metallopeptidase 3

Enzyme Information

3.4.24.65
Macrophage elastase.
based on mapping to UniProt P39900
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P39900
MMP12_HUMAN
Homo sapiens
Macrophage metalloelastase

PDB Structure

PDB 2JXY
External Links
Method SOLUTION NMR
Organism
Primary Citation
Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12
Bertini, I., Calderone, V., Fragai, M., Jaiswal, R., Luchinat, C., Melikian, M., Mylonas, E., Svergun, D.I.
J.Am.Chem.Soc.