CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphotransferase system, lactose/cellobiose-type IIA subunit
Functional Family Vacuolar protein sorting-associated protein 4A

Enzyme Information

3.6.4.6
Vesicle-fusing ATPase.
based on mapping to UniProt Q9UN37
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

Q9UN37
VPS4A_HUMAN
Homo sapiens
Vacuolar protein sorting-associated protein 4A

PDB Structure

PDB 2JQ9
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
ESCRT-III recognition by VPS4 ATPases.
Stuchell-Brereton, M.D., Skalicky, J.J., Kieffer, C., Karren, M.A., Ghaffarian, S., Sundquist, W.I.
Nature