CATH Domain 2jgaA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.150	DNA polymerase; domain 1
	1.10.150.340	Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain

Domain Context

CATH Clusters

Superfamily	Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain
Functional Family	Cytosolic 5-nucleotidase 3-like

Enzyme Information

3.1.3.91	7-methylguanosine nucleotidase. based on mapping to UniProt Q9H0P0 (1) N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate. (2) CMP + H(2)O = cytidine + phosphate. -!- The enzyme also has low activity with N(7)-methyl-GDP, producing N(7)-methyl-GMP. -!- Does not accept AMP or GMP, and has low activity with UMP.
3.1.3.5	5'-nucleotidase. based on mapping to UniProt Q9H0P0 A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. -!- Wide specificity for 5'-nucleotides.

UniProtKB Entries (1)

5NT3A_HUMAN

Homo sapiens

Cytosolic 5'-nucleotidase 3A

PDB Structure

PDB	2JGA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition. Wallden, K., Stenmark, P., Nyman, T., Flodin, S., Graslund, S., Loppnau, P., Bianchi, V., Nordlund, P. J.Biol.Chem.