CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Enzyme Information

2.4.2.19
Nicotinate-nucleotide diphosphorylase (carboxylating).
based on mapping to UniProt Q15274
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The reaction is catalyzed in the opposite direction. -!- Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.

UniProtKB Entries (1)

Q15274
NADC_HUMAN
Homo sapiens
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

PDB Structure

PDB 2JBM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Kinetic Characterization of Quinolinate Phosphoribosyltransferase (Hqprtase) from Homo Sapiens.
Liu, H., Woznica, K., Catton, G., Crawford, A., Bottinf, N., Naismith, J.H.
J.Mol.Biol.
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