1 keywords

CATH Domain 2j8jA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.50 3-Layer(bba) Sandwich
Topology 3.50.4 Hepatocyte Growth Factor
Homologous Superfamily 3.50.4.10 Hepatocyte Growth Factor

Domain Context

CATH Clusters

Superfamily Hepatocyte Growth Factor
Functional Family Coagulation factor XI

Enzyme Information

3.4.21.27
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P03951
FA11_HUMAN
Homo sapiens
Coagulation factor XI

PDB Structure

PDB 2J8J
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation.
Samuel, D., Cheng, H., Riley, P.W., Canutescu, A.A., Nagaswami, C., Weisel, J.W., Bu, Z., Walsh, P.N., Roder, H.
Proc.Natl.Acad.Sci.USA