CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.20 | Single Sheet |
|
2.20.25 | N-terminal domain of TfIIb |
|
2.20.25.90 | ADC-like domains |
Domain Context
CATH Clusters
| Superfamily | ADC-like domains |
| Functional Family | Formate dehydrogenase subunit alpha |
Enzyme Information
| 1.17.1.9 |
Formate dehydrogenase.
based on mapping to UniProt P07658
Formate + NAD(+) = CO(2) + NADH.
-!- The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centers, flavin and a molybdenum center. -!- Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase. -!- Formerly EC 1.2.1.2.
|
| 1.17.99.7 |
Formate dehydrogenase (acceptor).
based on mapping to UniProt P07658
Formate + acceptor = CO(2) + reduced acceptor.
-!- Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. -!- The two enzymes form the formate-hydrogen lyase complex. -!- The enzyme contains a selenocysteine residue. -!- Formerly EC 1.1.99.33.
|
UniProtKB Entries (1)
| P07658 |
FDHF_ECOLI
Escherichia coli K-12
Formate dehydrogenase H
|
PDB Structure
| PDB | 2IV2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Formate-Reduced E. Coli Formate Dehydrogenase H: The Reinterpretation of the Crystal Structure Suggests a New Reaction Mechanism.
J.Biol.Inorg.Chem.
|
